Tiam 1 Effects on Invasive Capacity of Gastric Cancer Cells in vitro and Underlying Mechanisms

Despite advances in surgical treatment, chemotherapy and radiotherapy, gastric cancer remains a major global health burden. The most recent estimates show that it is the fourth most common cancer and the second most common cause of cancer deaths worldwide (Lee et al., 2012; Mahar et al., 2012). Most victims of patients with gastric cancer died as a result of complications associated with recurrence and metastasis even after curative resection. But the invasion and metastasis of gastric cancer is a complex multistep process, in which invasiveness are necessary for gastric cancer cells to metastasize, and aberrant expression of some genes contributes to it (Lin et al., 2012). T lymphoma invasion and metastasis inducing factor 1 (Tiam 1), an important member of Dbl (diffuse B-cell lymphoma) oncogene family, was firstly identified from